What Is Polynucleotide (Rejuran) Treatment and How Does It Work?

Polynucleotide treatment is an injectable skin rejuvenation therapy that uses purified DNA fragments derived from salmon to stimulate collagen production, repair damaged skin cells, and restore hydration at a cellular level. It is available at NuVive Cosmetics in Edgewater, Perth, administered by AHPRA-registered Nurse Tracy Dixon.

What Are Polynucleotides?

Polynucleotides are long chains of nucleotides, the building blocks of DNA. In aesthetic medicine, these molecules are extracted from salmon DNA through an advanced purification process that removes all proteins and potential allergens, leaving behind a highly biocompatible substance that works with your body's own biology.

Once injected into the skin, polynucleotides act as a biostimulator. Rather than simply filling lines or adding volume, they trigger your body's natural repair mechanisms. This makes polynucleotide therapy fundamentally different from traditional dermal treatments. It works from the inside out, encouraging your skin to regenerate and heal itself over time.

The treatment has been widely used in South Korea and Europe for over a decade and has gained significant popularity in Australia as practitioners and clients recognise its ability to deliver genuine, long-lasting skin quality improvements.

How Does Polynucleotide Treatment Work?

Polynucleotide injections work through several biological pathways that collectively improve skin health:

• Collagen stimulation: The DNA fragments activate fibroblasts, the cells responsible for producing collagen and elastin. This leads to firmer, more resilient skin over the weeks following treatment.
• Cellular repair: Polynucleotides provide the raw materials that skin cells need to repair themselves. Damaged or ageing cells are supported in their natural regeneration cycle.
• Deep hydration: The molecules attract and bind water within the dermal layers, improving skin hydration from within rather than just on the surface.
• Anti-inflammatory action: Polynucleotides have a natural anti-inflammatory effect, helping to calm redness and improve overall skin tone and texture.
• Improved microcirculation: By promoting healthier blood flow in the treated areas, polynucleotides support better nutrient delivery to the skin.

What Areas Can Be Treated?

Polynucleotide treatment is versatile and can be applied to multiple areas of the face and body. The most commonly treated areas include:

• Face: Overall facial rejuvenation, including cheeks, jawline, and forehead. Improves fine lines, skin texture, and firmness.
• Under-eyes: One of the most popular applications. Polynucleotides can reduce dark circles, crepey skin, and hollowing beneath the eyes, an area that is notoriously difficult to treat with other methods.
• Neck: Addresses fine lines, crepiness, and loss of elasticity that commonly appear on the neck as we age.
• Hands: Restores hydration and volume to the backs of the hands, reducing the appearance of prominent veins and thin, papery skin.
• Decolletage: Improves sun damage, fine lines, and skin quality across the chest area.

During your consultation at NuVive Cosmetics, Tracy Dixon RN will assess your skin and recommend the most appropriate treatment areas based on your individual concerns and goals.

What to Expect During the Procedure

A polynucleotide treatment session at NuVive Cosmetics in Edgewater typically takes between 30 to 45 minutes, including preparation time. Here is what the process looks like:

1. Consultation: Your practitioner will assess your skin, discuss your goals, review your medical history, and determine whether polynucleotide therapy is suitable for you.
2. Preparation: The treatment area is cleansed and a topical anaesthetic cream is applied to minimise discomfort. This is left on for approximately 20 minutes.
3. Injection: Using fine needles or a cannula technique, the polynucleotide solution is injected into the targeted areas using a series of small deposits across the treatment zone.
4. Aftercare: You will receive aftercare instructions. Most clients can return to normal activities immediately, though mild redness and swelling at injection points is expected for 24 to 48 hours.

Recovery is minimal. You may notice small bumps at the injection sites which typically settle within a few hours to a day. It is recommended to avoid intense exercise, saunas, and direct sun exposure for 24 to 48 hours after treatment.

How Many Sessions Are Needed?

Most clients see noticeable improvements after a single session, but optimal results are typically achieved with a course of two to three treatments spaced four to six weeks apart. This allows each session to build upon the previous one as collagen production increases progressively.

After completing the initial course, maintenance treatments are generally recommended every six to nine months to sustain the benefits. Your practitioner will tailor the treatment schedule to your individual skin needs and desired outcomes.

Who Is a Good Candidate?

Polynucleotide treatment is suitable for a wide range of individuals. You may be a good candidate if you are experiencing:

• Fine lines and loss of skin elasticity
• Dull, dehydrated, or tired-looking skin
• Dark circles or crepey skin under the eyes
• Sun-damaged skin on the face, neck, or chest
• Early signs of ageing and want to take a preventative approach
• Skin that has not responded well to topical treatments alone

Polynucleotide therapy is suitable for most skin types and tones. However, it may not be appropriate for those who are pregnant or breastfeeding, have active skin infections in the treatment area, or have a known allergy to fish-derived products. A thorough consultation with an AHPRA-registered practitioner is essential before proceeding.

Why Choose NuVive Cosmetics in Edgewater, Perth?

At NuVive Cosmetics, all polynucleotide treatments are performed by Tracy Dixon, a Registered Nurse with over 14 years of clinical experience including intensive care nursing. Tracy is AHPRA-registered and committed to delivering safe, evidence-based aesthetic treatments in a warm and professional clinical environment.

Located at 4/21 Joondalup Drive, Edgewater WA 6027, NuVive Cosmetics serves clients across Perth's northern suburbs including Joondalup, Wanneroo, Kingsley, Woodvale, and Currambine. Every treatment begins with a comprehensive consultation to ensure polynucleotide therapy is the right option for your skin goals.